Design, catalyst-free synthesis, DFT study and anticancer assessment of new 2,9-disubstituted purine-6-carboxamides
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A green, catalyst-free synthesis of seventeen new 2,9-disubstituted purine-6-carboxamides (5 and 6) designed as EGFR inhibitors in high yields (85-93%) was accomplished. DFT analysis revealed the formation of an energetically favorable oxazolidine transition s... ...
