A porcine congenital deafness model with unconditional knockout of GJB2 generated by CRISPR/Cas9 genomic editing
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GJB2, the primary gene responsible for DFNB1, the most prevalent non-syndromic hearing loss (NSHL), has variants that account for over 50% of all prelingual hearing loss (HL). Mice are the main model for congenital hearing loss (CHL) research, but they have de... ...
