A time-sensitive plasticity distinguishes the rapid and sustained synaptic actions of ketamine from its (2R, 6R)-hydroxynorketamine metabolite
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(R,S)-ketamine (ketamine) induces rapid and sustained antidepressant-relevant neuroplastogenic effects in vivo. The metabolite (2R,6R)-hydroxynorketamine (2R6R) forms shortly after the administration of ketamine, and independently elicits rapid plasticity and ... ...
