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Directed evolution of phage Romulus in biofilm-embedded Staphylococcus aureus: mutations in baseplate proteins enhanced its antibiofilm activity

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The ability of Staphylococcus aureus to form biofilm and the emergence of multidrug-resistant strains make staphylococcal infections often chronic and difficult to treat. To face these challenges, alternative or adjunct strategies to antibiotics are urgently r... ...