Unveiling Immune System Perturbations in Early Development Through Zebrafish Models of NADHX Repair Deficiency
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The vital cofactors NADH and NADPH are prone to hydration, forming hydroxylated redox-inactive derivatives (NADHX and NADPHX) in cells. These damaged metabolites are repaired by two highly conserved enzymes, an NAD(P)HX dehydratase (NAXD) and an NAD(P)HX epime... ...
