Discovery of pyrrolopyrimidinone inhibitors of the BCL6-SMRT corepressor interaction
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B-cell lymphoma 6 (BCL6) is a transcriptional repressor protein central to the development and maintenance of germinal centers (GCs) during the humoral immune response. BCL6 is often deregulated in diffuse large B-cell lymphoma (DLBCL), a type of non-Hodgkin'... ...
