Discovery of non-opioid peptides that selectively relieve mechanical pain in rodents through inhibition of TRPV4 channels
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Mechanical hyperalgesia is a primary symptom of clinical pain; there remains a therapeutic challenge for severe mechanical and chronic forms of neuropathic pain. The 34-amino-acid neuropeptide GsMTx4, isolated from Tarantula spatulata, was identified as a sele... ...
