A Validated LC-MS/MS Method for Unbound Rifapentine Quantitation Reveals Nonlinear Plasma Protein Binding and Comparable Free Fractions Between Adults and Children with Tuberculosis
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Background and objective: Therapeutic drug monitoring (TDM) typically uses total drug concentration (Ct), but pharmacological effects depend on free concentration (Cf), especially for highly protein-bound drugs like rifapentine (... ...
