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Comprehensive database enables the UHPLC-Q-orbitrap-MS/MS method to discover 16 "overlooked" compounds and supply three new pharmacopoeia quality-markers for charred Semen Arecae (Jiaobinglang)

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Background: the emerging UHPLC-Q-orbitrap-MS/MS method is not efficient for the deep analysis of charred Chinese herbal medicines (CHMs) due to the lack of a comprehensive database. This study tried to develop a new strategy, i.e., database-affinity ultra-high... ...