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Matrix-Tolerant Quantification of THC and THCA in Complex Cannabis Products Using In-Sample Calibration with Multiple Isotopologue Reaction Monitoring

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Accurate quantification of Δ9-tetrahydrocannabinol (THC) and Δ9-tetrahydrocannabinolic acid (THCA) across diverse cannabis- and hemp-derived products remains challenging due to severe matrix effects, wide concentration variability, and the need for matrix-ma... ...