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Enhancing tumor ROS generation via nanozyme-amplified photodynamic therapy with oxygen-supplying bacterial OMVs

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In this study, OMV@Hb-Ce6-Mn was constructed by co-loading hemoglobin (Hb) and chlorin e6 (Ce6) onto OMVs, followed by modification with manganese dioxide (MnO2) nanoparticles. OMV@Hb-Ce6-Mn significantly suppressed tumor growth and elicited potent systemic an... ...