Estimation of the metabolic stability of omipalisib in human liver microsomes employing an ultra-fast UPLC-MS/MS approach: in silico screening for structural alarms and metabolic lability
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Omipalisib (OMP) is a powerful dual inhibitor of the mTOR and PI3K enzymes, demonstrating anti-tumor effectiveness in multiple cancer types. No reported UPLC-MS/MS method with in silico metabolism analysis and combined green metrics has been reported for OMP; ... ...
