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Multisite Cre-lox Recombination Enables Regulatory Mechanism Elucidation and Systematic Engineering of Echinocandin B Biosynthesis in Aspergillus nidulans

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Echinocandin B (ECB), a cyclic lipohexapeptide for synthesizing antifungal drugs, is produced by the nonribosomal peptide synthetase gene cluster in Aspergillus nidulans. However, industrial production remains limited by the inefficiency of production capacity... ...