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Cross-organ single-cell integration identifies liver-specific fibroblast programs and HGF-MET/AGT-AGTR1B axes that link fibrosis to hepatocarcinogenesis

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Background: Fibrosis is a pan-organ wound-healing program, yet stromal mechanisms that are liver-selective and connect liver fibrosis to hepatocellular carcinoma (HCC) remain incompletely defined. ... ...