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Selective detection of membrane-bound amyloid-β oligomers using SERS "hot-spots": toward early diagnostics for Alzheimer's disease

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A key characteristic of Alzheimer's disease (AD) is the build-up of amyloid-β (Aβ) fibrillar aggregates, commonly known as plaques, within the brain. Current diagnostic tools, such as MRI, CT, and PET, primarily detect neurodegeneration or plaque burden, li... ...