Prediction of Monoclonal Antibodies Pharmacokinetics in Human: Identification of a Reference Neonatal Fc Receptor (FcRn) Binding Affinity Using Physiologically Based Pharmacokinetic (PBPK) Modeling
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Prediction of monoclonal antibody (mAb) pharmacokinetics (PK) in drug development remains challenging due to the lack of a standardized method for predicting elimination based on mechanistic pathways. Among the processes implemented in the physiologically base... ...
