Impact of Metformin and Diabetes on Tumor Response to Total Neoadjuvant Therapy in Advanced Rectal Cancer: A Multicenter Retrospective Cohort Study
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Aim: Diabetes mellitus (DM) is associated with impaired response to neoadjuvant chemoradiotherapy in rectal cancer. Metformin may enhance treatment response by improving tumor oxygenation and inhibiting cell growth and proliferat... ...
