A piperidinyl amide compound enhances Ca2+ signaling in cardiomyocytes by increasing activity of Ca2+ pump
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In adult cardiomyocytes, the type 2a sarco/endoplasmic reticulum Ca2+-ATPase (SERCA2a) plays a vital role in intracellular Ca2+ regulation. Reduced SERCA2a function has been associated with decreased myocardial contraction and cardiac output in several heart d... ...
