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Petasis-amide coupling enabled microwave-assisted synthesis of bis-benzothiazoles with safety profiling and antiprotozoal evaluation

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A series of amide-linked bis-benzothiazoles was synthesized using an efficient microwave-assisted strategy that integrates the Petasis multicomponent reaction with HATU-mediated amide coupling. The methodology enabled rapid reactions (2 and 5 min) with high is... ...