DSN-based Host DNA Depletion for Simultaneous Detection of DNA and RNA Pathogens in next-generation sequencing
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In recent years, nucleic acid sequencing has been increasingly used in clinical pathogen detection. Typically, 20-100 million metagenomic reads are generated per sample, but 90-99% originate from host nucleic acids, leaving only 1-2 million for microbial ident... ...