Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex
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The guanosine triphosphate (GTP)-bound state of the heterodimeric Rag GTPases functions as a molecular switch regulating mechanistic target of rapamycin complex 1 (mTORC1) activation at the lysosome downstream of amino acid fluctuations. Under low amino acid c... ...
