Hydrogen bonding-enabled gold catalysis: ligand effects in gold-catalyzed cycloisomerization of 1,6-enynes in hexafluoroisopropanol (HFIP)
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Hydrogen bonding has recently emerged as a powerful yet underexplored tool to enable gold(I) catalysis. Here, we demonstrate that HFIP can directly activate [Au(L)Cl] complexes through hydrogen bonding, in the cycloisomerization of 1,6-enynes under mild condit... ...
