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Modelling EWS::FLI1 protein fluctuations reveal determinants of tumor plasticity in Ewing sarcoma

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Tumor cell plasticity drives metastasis and therapy resistance, yet its regulation by oncoprotein dosage dynamics remains poorly understood. In Ewing sarcoma (EwS), variations in EWS::FLI1 (EF) fusion oncoprotein activity have been associated with epithelial-m... ...