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Assessing PARP trapping dynamics in ovarian cancer using a CRISPR-engineered FRET biosensor

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Poly(ADP-ribose) polymerase inhibitors (PARPi) have revolutionized the treatment of ovarian high-grade serous carcinoma (HGSC), particularly in homologous recombination-deficient tumors. However, the emergence of resistance poses a critical challenge, as over ... ...