Enantioselective Synthesis of Functionalized 2,2-Disubstituted Piperidines Enabled by Pd-Catalyzed Decarboxylative Asymmetric Allylic Alkylation
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Herein, we report a palladium-catalyzed decarboxylative asymmetric allylic alkylation (Pd-DAAA) for the synthesis of enantioenriched 2,2-disubstituted piperidines. This method efficiently constructs aza-quaternary stereocenters with high enantioselectivity and... ...