Low-input proteomics identifies vWF as a negative regulator of Tet2 mutant hematopoietic stem cell expansion
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Despite rapid advances in mapping genetic drivers and gene expression changes in hematopoietic stem cells (HSCs), few studies exist at the protein level. We perform a deep, multi-omics characterization (epigenome, transcriptome, and proteome) of HSCs in a mous... ...