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Design and synthesis of sorafenib-inspired benzofuran hybrids as VEGFR-2 inhibitors: antiproliferative evaluation, mechanistic insights, and docking studies in hepatocellular carcinoma

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Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide owing to its high metastatic potential. Vascular endothelial growth factor receptor-2 (VEGFR-2), a key regulator of angiogenesis and cell proliferation, is a critical thera... ...