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The CCR4-NOT deadenylase complex mediates tubulin autoregulation via specific adapters CNOT10 and CNOT11

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Tubulin autoregulation maintains cellular microtubule homeostasis by triggering rapid degradation of tubulin mRNAs in response to an increase in soluble α- and β-tubulin levels. Through siRNA knock-down of several RNA decay pathways coupled with Roadblock-qP... ...