Discovery of novel progesterone-heterocyclic conjugates and their encapsulated polymeric nanoparticles as potential CDK8 inhibitors: lung cytotoxicity evaluation, gene expression, and molecular docking
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CDK8 is overexpressed in many cancers and represents a potential target for developing new anticancer agents. To identify promising antineoplastic compounds as CDK8 inhibitors, progesterone-heterocyclic conjugates were synthesized through multicomponent reacti... ...
