Identification and characterization of candidate inhibitors of the SARS-CoV-2 nsp14 3'-5' exoribonuclease
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Coronaviruses such as SARS-CoV-2 possess the largest positive-sense RNA virus genomes (30 kb). This poses a fidelity problem as the inherent lack of proof-reading capacity of the viral RNA-dependent RNA polymerase results in a high level of mutation. To overco... ...
