Deoxyuridine as a surrogate marker of thymidylate synthase inhibition contributes to a multivariable model predicting 5-FU/LV response in metastatic colorectal cancer
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Background: Colorectal cancer (CRC) chemotherapy is based on 5-fluorouracil (5-FU) and the folate leucovorin (LV). The active metabolites of these compounds, 5-fluorodeoxyuridine monophosphate (FdUMP) and 5,10-methylenetetrahydro... ...
