An atypical non-ribosomal peptide cyclase catalyzing homochiral coupling with cyclic amine nucleophile
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The macrocyclic scaffolds of non-ribosomal peptides (NRPs) are typically constructed by thioesterase (TE) domains, α/β-hydrolase fold enzymes located at the C-termini of non-ribosomal peptide synthetases (NRPSs). By employing various nucleophiles, TEs serve ... ...
