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Targeting endoplasmic reticulum stress-induced CLGN resensitizes hepatocellular carcinoma to apoptosis: paeonol synergistically enhances efficacy by dual inhibition of CLGN and NF-κB

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Purpose: Endoplasmic reticulum stress (ERS) drives hepatocellular carcinoma (HCC) progression and therapy resistance. This study identifies Calmegin (CLGN) as a novel ERS-induced pro-survival factor and explores shCLGN combined w... ...