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Extracellular matrix-inspired multi-morphology microspheres harness osteogenic-prone stem cells to recruit and reprogram adjacent stem cells for synergistic bone regeneration

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Governed by epigenetic regulation, distinct types of adult stem cells exhibit lineage-specific differentiation biases. Osteogenic-prone stem cells might recruit, proliferate, and induce osteogenesis in adjacent osteogenic-weak stem cells, constituting a key me... ...