Redox phenotype confers T cell-exclusion microenvironment and resistance to immunotherapy by suppressing STING/ MDA5 expression and interferon signaling in lung cancers harboring KEAP1/ STK11 mutations
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Background: KEAP1 and STK11 are frequently mutated in NSCLC, and are associated with compromised response to immunotherapy, the underlying mechanism of which is not fully understood. ... ...
