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Oncostatin M induced by STAT5-activating oncogenes promotes disease progression in hematologic malignancies

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Understanding the interplay between oncogenic mutations and the tumor microenvironment could help improve therapy for hematological malignancies. We found that the STAT5-activating oncogenes JAK2 p.V617F, FLT3-ITD, and BCR::ABL1 induce oncostatin M (OSM), whic... ...