Down-regulation of gastrin-releasing peptide in medial orbitofrontal cortex to nucleus accumbens projections contributes to allodynia and negative affect
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Chronic pain is debilitating with affective comorbidities, but neural mechanisms linking nociception and emotional processing are unclear. Here, we identify the gastrin-releasing peptide (GRP)/GRP receptor (GRPR) system in the medial orbitofrontal cortex (MO)-... ...
