The oncometabolite R-2-hydroxyglutarate inhibits microglial activation via the FTO/NF-κB pathway
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Introduction: Mutations in isocitrate dehydrogenase 1 (mIDH1) generate the oncometabolite (R)-2-hydroxyglutarate (R-2HG), which promotes tumorigenesis by inhibiting α-ketoglutarate-dependent enzymes and altering the epigenetic l... ...
