Combinatorial use of VHL and KEAP1 PROTACs reveals unexpected synergy and hook effect relief
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Proteolysis-targeting chimeras (PROTACs) are bifunctional molecules bridging a protein with an E3 ubiquitin ligase, promoting its ubiquitylation and degradation. However, PROTACs are not without limitations, including suboptimal target degradation and the "ho... ...
