Orthogonal validation of anaplastic lymphoma kinase (ALK) immunohistochemistry with molecular analysis for ALK gene rearrangement is required to finetune staining protocols with the D5F3 clone and can impact external quality assessment
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Immunohistochemistry (IHC) for anaplastic lymphoma kinase (ALK) is used to screen tumours for ALK gene rearrangements, which generally result in ALK protein overexpression, depending on the fusion partner. Here, an interlaboratory validation of three IHC proto... ...
