UBA6 specificity for ubiquitin E2 conjugating enzymes reveals a priority mechanism of BIRC6
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In mammals, ubiquitylation is orchestrated by the canonical ubiquitin-activating E1 enzyme UBA1 and the orthogonal E1 UBA6. Growing evidence underscores the essentiality of both E1s, which differentiate between 29 active ubiquitin-conjugating enzymes (E2s). Th... ...
