Stereochemical Reassignment by Total Synthesis of an Ocular Pyridinium Bisretinoid of Retinal Pigment Epithelium Lipofuscin: iiso-A2E Is i-A2E
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The stereoselective synthesis of recently discovered lipofuscin fluorophore iiso-A2E, a C3,C4-bis-polyenylpyridinium salt derived from all-trans-retinal, which has been detected in human, pig, mouse, and bovine eyes, has been completed. The Suzuki-Miyaura cros... ...
