Abnormal nuclear and nucleolar immunoreactivity of p16INK4a represents a frameshift alteration in CDKN2A: the E6H4 clone recognizes the "p14ARF::p16INK4a" chimeric protein
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In p16INK4a immunostaining, block positivity (i.e., strong nuclear/nuclear-cytoplasmic staining) is a widely acknowledged surrogate marker of HPV-associated cancers. Thus, immunohistochemistry using the anti-p16INK4a clone E6H4 has been approved as an in vitro... ...
