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Methotrexate Exhibits a Dual Role in Regulation of CD4+ T Follicular Helper (Tfh) Cell Differentiation and Activity

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Methotrexate (MTX) is one of the most prevalent drugs used in the treatment of autoimmune disorders as it has an established role in preventing T and B cell proliferation which reduces the severity of autoimmunity. However, MTX in combination with several othe... ...