Influence of Intrinsic Electric Fields and 2-His-1-Carboxylate/Chloride Facial Triad on the Active Sites of 2-Oxoglutarate-Dependent Enzymes
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Iron(II)- and 2-oxoglutarate-dependent (Fe(II)/2OG) oxygenases form a large family of nonheme enzymes containing the Fe(II) center coordinated by two histidine residues and either a carboxylate or halide ligand, with 2OG acting as a cosubstrate. Although these... ...
