DDX5 is required for JAK2V617F-induced cell proliferation and tumorigenesis independent of its RNA helicase activity
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The constitutively active Janus kinase 2 mutant (JAK2V617F) is a major driver of myeloproliferative neoplasms (MPNs). Our previous studies demonstrated that JAK2V617F upregulates the expression of the RNA helicase DDX5 via activation of the transcription facto... ...
