PolED: a manually curated database of functional studies of POLE and POLD1 variants reported in humans
{{output}}
Human POLE and POLD1 genes encode DNA polymerases responsible for genome replication and proofreading of DNA synthesis errors. Germline and somatic POLE/POLD1 mutations compromising the polymerase fidelity cause cancers with high mutational burden. Ultramutati... ...
