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Akkermansia Muciniphila-Inspired Oral siRNA Delivery by Active Matrix-Penetration and Intracellular Endoplasmic Reticulum Accumulation

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Oral delivery of small interfering ribonucleic acid (siRNA) is highly challenging due to the multiple barriers present in the gastrointestinal tract and within cells. Herein, inspired by intestinal Akkermansia muciniphila, the use of Akkermansia muciniphila me... ...