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Discovery of CRBN-recruiting PROTAC degraders of the METTL3-METTL14 complex

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METTL3 and METTL14, key components of the m6A writer complex, are frequently overexpressed in various malignancies, including acute myeloid leukemia (AML), where aberrant methylation has been linked to the upregulation of oncogenic transcription. Therefore, ta... ...