Plasmid-transformed Bifidobacterium longum 105A secreting β-glucuronidase for prodrug conversion of SN-38 glucuronide
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The development of tumor-selective prodrug activation strategies remains a major challenge in cancer pharmacotherapy. In this study, we focused on SN-38 glucuronide (SN-38G), a highly hydrophilic prodrug with low membrane permeability that remains pharmacologi... ...
